Anthony Martial, Eric Bailly and Jesse Lingard all arrived at Carrington on Saturday morning but they were not observed boarding the plane for the short flight north.
Aaron Wan-Bissaka, Phil Jones, Luke Shaw and Paul Pogba were also absent as expected.
United’s injuries could mean more involvement for United’s talented youngsters at Newcastle.
Brandon Williams made his first start for the club at AZ Alkmaar on Thursday night and is included for the Newcastle fixture, as are Angel Gomes, Tahith Chong and Mason Greenwood.
United head to St James’ Park having failed to win any of their last 10 away fixtures. It’s a dire run they need to end against a Premier League club in decline and Solskjaer is confident they are getting closer to that elusive away points.
“I do feel its going to come. There’s no point me talking about it. I’ll get your questions until we do win. If we don’t we’ll get this on Sunday as well,” he said.
“We are a team that can be set up well to play away from home. Sometimes you can play on the counter. [On Thursday] we didn’t really get the counter-attacks as we wanted to.”
Newcastle are desperate for a win themselves, with Steve Bruce coming under heavy pressure at St James’ Park, and Solskjaer isn’t expecting any favours from his former teammate.
“As managers we don’t want to give anyone any favours when we play each other,” he said. “Brucey’s going to set up a team to win. I’m going to set up a team to try to win.
“It’s a great stadium to play at. We’re looking forward to the game. We’ve hopefully got many players fresh for Sunday.”